The movie's plot revolves around Van Helsing (Jackman), a skilled hunter who works for a secret organization dedicated to eradicating supernatural threats. He's tasked with taking down Count Dracula (Richard Roxburgh), Frankenstein's monster (Kevin Grevioux), and a werewolf, all of which have escaped and are wreaking havoc on London. Along the way, Van Helsing teams up with Anna Valerious (Kate Beckinsale), a Romanian princess on a quest for revenge against Dracula.