In Naruto Shippuden: Ultimate Ninja Storm, players take on the role of various characters from the Naruto series, including Naruto Uzumaki, Sasuke Uchiha, and Sakura Haruno. The game features a dynamic fighting system, allowing players to perform combos, jutsu (ninja techniques), and interact with the environment. The game's story mode follows the events of the Naruto Shippuden anime series, with over 40 playable characters to unlock and master.