Vichitra's breakthrough performance came with the 2005 film "Chennai Express," where she played the lead opposite Vijay. The film's success catapulted her to fame, and she went on to appear in a string of successful films, including "Thirupathi" (2006), "Pokkisham" (2007), and "Sivaji" (2007). Her on-screen chemistry with leading actors like Vijay, Ajith Kumar, and Suriya has been a major draw for her films.