The movie follows Rizwan Khan, a Muslim man with Asperger's syndrome, who lives in San Francisco with his American wife, Nandini. Rizwan's life changes when he meets Mandira, a Hindu woman, and her son, Rahul. Rizwan falls in love with Mandira and decides to visit her in India. However, Rizwan faces difficulties in India due to his Muslim name and his Asperger's syndrome. He experiences prejudice and hostility from people who assume he is a terrorist.